Category Archives: Publications!

Mammalian TRIM67 functions in brain development and behavior

Check out the consequences of genetic deletion of Trim67.

Deletion of murine Trim67 results in malformations of a subset of subcortical brain regions and of cortical and subcortical myelinated fiber tracts, as well as deficits in spatial memory, motor function, sociability and sensorimotor gating. Interactions between TRIM67 and both the netrin receptor DCC and TRIM9, and abnormalities in netrin-sensitive brain regions are noted. We conclude that TRIM67 is critical for appropriate brain development and behavior.