Selected Publications

Complete list of work:

S.L. Gupton NCBI Link to Full Publications

Selected Publications:

Plooster, M., G. Rossi, M.S. Farrell, J.C. McAfee, J.L. Bell, M. Ye, G.H. Diering, H. Won, S.L. Gupton*, and P. Brennwald*. 2021. Schizophrenia-Linked Protein tSNARE1 Regulates Endosomal Trafficking in Cortical Neurons. J. Neurosci. 41:9466–9481. doi:10.1523/jneurosci.0556-21.2021. *(co-corresponding)

Urbina, F., and S.L. Gupton. 2021. Automated Detection and Analysis of Exocytosis. JoVE (Journal Vis. Exp. e62400. doi:10.3791/62400.

Ho, C.T., and S.L. Gupton. 2021. Neurons | Establishing and Maintaining Neuron Morphology. Encycl. Biol. Chem. III. 345–357. doi:10.1016/B978-0-12-819460-7.00240-1

Mutalik, S.P., and S.L. Gupton. 2021. Molecular Sciences Glycosylation in Axonal Guidance. Int. J. Mol. Sci. 22:5143. doi:10.3390/ijms22105143.

Urbina, F.L., S. Menon, D. Goldfarb, R. Edwards, M. Ben Major, P. Brennwald, S.L. Gupton Correspondence, and S.L. Gupton. 2021. TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47. Cell Rep. 34. doi:10.1016/j.celrep.2021.108743.

Menon, S., D. Goldfarb, C.T. Ho, E.W. Cloer, N.P. Boyer, C. Hardie, A.J. Bock, E.C. Johnson, J. Anil, M. Ben Major, and S.L. Gupton*. 2020. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Mol. Biol. Cell. mbc.E20-10-0622. doi:10.1091/mbc.e20-10-0622.

Menon, S; Goldfarb, D; Cousins, EM; Major, MB; Gupton, SL *(2020). The ubiquitylome of developing cortical neurons. microPublication Biology. 10.17912/micropub.biology.000333.

Urbina FL, Gupton S.L.* SNARE-Mediated Exocytosis in Neuronal Development. (2020) Front Mol Neurosci. 2020;13:133. Published 2020 Aug 7. doi:10.3389/fnmol.2020.00133

McCormick L.E. and Gupton S.L.* (2020) Mechanistic Advances in Axonal Pathfinding. Current Opinion in Cell Biology.63:11-19.

Nicholas P. Boyer, Laura E. McCormick, Shalini Menon, Fabio L. Urbina, Stephanie L. Gupton (2020).  A pair of E3 ubiquitin ligases compete to regulate filopodial dynamics and axon guidanceJ Cell Biol ; 219 (1): e201902088.

Menon, S., and Gupton S.L. (2018). Recent advances in branching mechanisms underlying neuronal morphogenesis. F1000Research, 7, 1779.

Do LD, Gupton S.L. , Tanji K, Bastien J, Brugière S, Couté Y, Quadrio I, Rogemond V, Fabien N, Desestret V, Honnorat J. TRIM9 and TRIM67 are new targets in paraneoplastic cerebellar degeneration.  Cerebellum. 2018 Oct 22. doi: 10.1007/s12311-018-0987-5. [Epub ahead of print]

Boyer, N. P., and S. L. Gupton. 2018 . Revisiting Netrin-1: One who guides (axons). Frontiers in Cellular Neuroscience. 2018 Jul 31;12:221. doi: 10.3389/fncel.2018.00221.

Boyer, N. P., Monkiewicz, C., Menon, S., Moy, S. S., & S.L. Gupton. 2018. Mammalian TRIM67 Functions in Brain Development and Behavior. eNeuro, 5(3), ENEURO.0186–18.2018.

Urbina, F.L., S.M. Gomez, and S.L. Gupton. 2018. Spatiotemporal organization of exocytosis emerges during neuronal shape change. J Cell Biol. jcb.201709064. doi:10.1083/jcb.201709064.

Plooster, M., S. Menon, C.C. Winkle, F.L. Urbina, C. Monkiewicz, K.D. Phend, R.J. Weinberg, and S.L. Gupton. 2017. TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching.  Mol Biol Cell.  28(18):2374-2385.  doi:10.1091/mbc.E16-08-0594.

Winkle, C.C., Olsen, R.H.J., Kim, H., Moy, S.S., Song, J.,  Gupton, S.L. 2016 Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory. The Journal of Neuroscience. 36(18):4940-4958.

Winkle, C.C., Taylor, K. L., Dent, E. W., Gallo, G., Greif, K. F.,  and Gupton, S.L. 2016 Beyond the cytoskeleton: The emerging role of organelles and membrane remodeling in the regulation of axon collateral branches. Developmental Neurobiology. In Press.

Winkle, C. C., Hanlin, C. C., Gupton, S. L. 2016. Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis. J. Vis. Exp. (109), e53743, doi:10.3791/53743.

Menon, S., and S.L. Gupton. 2016. Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development. Int Rev Cell Mol Biol. Elsevier Vol 322: Chapter 3: 183-246.

Winkle, C.C., and S.L. Gupton. 2016. Membrane Trafficking in Neuronal Development: Ins and Outs of Neural Connectivity. In International Review of Cell and Molecular Biology. Elsevier. Vol 322: Chapter 4: 247-280.

Menon, S., N.P. Boyer, C.C. Winkle, L.M. McClain, C.C. Hanlin, D. Pandey, S. Rothenfußer, A.M. Taylor, and S.L. Gupton. 2015. The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance. Developmental Cell. 35:698–712. doi:10.1016/j.devcel.2015.11.022.

Taylor, A.M., S. Menon, and S.L. Gupton. 2015. Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients. Lab on a chip. doi:10.1039/C5LC00503E.

Barzik, M., McClain, L. M., Gupton, S. L. & Gertler, F. B. Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function. Mol Biol Cell (2014). doi:10.1091/mbc.E14-02-0712

Winkle, C. C. McClain, L.M. Valtschanoff, J.G., Park C.S., Maglione, C. and Gupton, S.L. (2014) A novel Netrin-1-sensitive mechanism promotes local SNARE-mediated exocytosis during axon branching. J Cell Biol 205, 217–232 .

S.L. Gupton, D. Riquelme, S.K. Hughes-Alford, J. Tadros, S.S. Rudina, R.O.Hynes, D. Lauffenburger, and F.B. Gertler (2012). Mena binds α5 integrin directly and modulates α5β1 function. Journal of Cell Biology. Aug 20, 2012; 198 (4)

Dent EW, Gupton SL, Gertler FB. (2011).  The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harb Perspect Biol. Mar 1;3(3). pii: a001800. doi: 10.1101/cshperspect.a001800.

Gupton, S.L. and Gertler, F.B. (2010). Integrin signaling switches the cytoskeletal and exocytic machinery driving neuritogenesis. Developmental Cell.  18(5)725-36.

Gupton, S.L., and Gertler, F.B. (2007). Filopodia: the fingers that do the walking. Science STKE 2007, 400.

Gupton, S.L., Eisenmann, K., Alberts, A.S., and Waterman-Storer, C.M. (2007). mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration. Journal of Cell Science. 120:3475-3487.

Gupton, S.L., and Waterman-Storer, C.M. (2006). Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration. Cell 125:1361-1374.

Gupton, S.L., Collings, D.A., and Allen, N.S. (2006). Endoplasmic reticulum targeted GFP reveals ER organization in tobacco NT-1 cells during cell division. Plant Physiology and Biochemistry. 44:95-105.

Gupton, S. L., Anderson, K. L., Kole, T. P., Fischer, R. S., Ponti, A., Hitchcock-DeGregori, S. E., Danuser, G., Fowler, V. M., Wirtz, D., Hanein, D., and Waterman-Storer, C. M. (2005). Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. Journal of Cell Biology. 168:619-631.

Ponti, A., M. Machacek, S.L. Gupton, C.M. Waterman-Storer, and G. Danuser. 2004. Two distinct actin networks drive the protrusion of migrating cells. Science. 305:1782–1786.

Gupton, S.L., Salmon, W.C., and Waterman-Storer, C.M. (2002). Converging populations of f-actin promote breakage of associated microtubules to spatially regulate microtubule turnover in migrating cells. Current Biology. 12:891-899.